This chapter on ‘Artificial Intelligence and Emerging Technologies: Exploring Opportunities through Place-Based Innovation’ looks at how staying competitive in the global economy depends on transnational activities and participation in global value chains and explores the growing importance of the role of transnational and interregional cooperation in facilitating innovation activities in new and emerging technological areas connected to a new generation policy experiments in the field of research and innovation.

The publication on ‘Measuring the Impact of Innovation Districts‘ proposes a generic and algorithmic methodology to identify and measure the success of innovation districts. Different sets of large-scale geospatial data have been combined with well-established machine learning methods and in-depth statistical analysis. As a result, a quantitative methodology supports the policy-making process in identifying urban areas with a high concentration of innovation activities and a high growth potential.

The chapter on ‘Connecting Urban and Regional Innovation Ecosystems to Enhance Competitiveness’ in the Palgrave Encyclopedia of Urban and Regional Futures explores why an increasing number of regions and cities in close cooperation with quadruple helix partners combine place-based innovation strategies with cross-border innovation networks. Such collaborations may result in a wide variety of organisational solutions, which allow actors to overcome different barriers and concerns of innovation.

The methodological manual documents ­­the optimised processes of initiating and managing international strategic partnerships working towards synergies of joint actions, proposing a comprehensive yet straightforward evaluation framework that covers the entire workflow from idea conception to evaluation.

This paper focuses on international partnerships’ facilitation of global engagement of stakeholders in support of the implementation of the Sustainable Development Goals. By exploring thematic S3 partnerships as an example of such interregional collaborative arrangements, this paper explores how these activities can contribute to the attainment of the Global Goals.

The paper outlines a conceptual framework of how transnational cooperation may strengthen regional place-based development strategies and improve regional innovation capabilities. Key analytical concepts are proximity, knowledge complexity, stakeholder analysis and cluster emergence.

The chapter on international partnerships documents key steps made by the European Commission, regional partners, and clusters in organising these networks through scoping, mapping, monitoring, and multi-level governance systems. The chapter presents a conceptual framework for analysing how this experiment may impact transnational learning, entrepreneurial discovery processes and innovation ecosystems through the concepts of regional knowledge space, relational knowledge space and third space.